Issa

Issa was the first wife of Zadimus and matriarch of the Vampire Territory as well as the biological mother of Lycidas.

Personality
Issa is known to be cunning and manipulative as a vampire of the Vampire Royal Family. She is always after power and she enjoys watching those who oppose her plans suffer. Issa hates Renee, due to her stealing Zadimus away from her. By all accounts, Issa's hatred for Tsubaki, Soren and Renee stems from the love her husband shows them and her hatred towards humanity is actually just done to scorn Renee, meaning that she literally wants to wipe out mankind simply to scorn the ideals of Zadimus' mistress.

She is also shown to have a strong, biased pride in her son Lycidas. Sadistic to the last, she shows great joy in the agony of her enemies, especially Renee and those around her. Even when her army of vampires turned into ghouls, not only was she directly responsible, she displayed no remorse in the least and actually seemed to be under the impression, perhaps from her own vanity, that they were improved.

Perhaps her most obvious trait, and clearly her greatest weakness, is Issa's sheer arrogance. Her pride in her position as head of the Isakaya family and her overall power and intelligence vastly exceeds any tendency for caution. As a result of this, Issa has a habit of underestimating her foes or prematurely declaring victory, as she has been repeatedly surprised to find her foes stronger than she believed they'd be or still alive after a supposedly devastating attack. She has pride in the Izakaya family name and assumed her Vampire Army to be unbeatable because of it, but was not above turning them into ghouls when they did fail.

All in all, Issa is amoral, narcissistic, arrogant, highly ambitious and very begrudging, but the heart of her actions, all of them in fact, seem rooted solely around her hatred for Zadimus' mistress Renee for stealing him away from her.

Magic and Abilities
Vampirism: Though the full extent of her abilities are only briefly shown, Issa is considered to be extremely powerful as far as vampires go.
 * Immense Strength: Issa possesses monstrous physical strength, being able to tear an enormous stone column out of the foundation of the Hanging Garden and hurl it a great distance with ease.
 * Immense Speed: Issa is extremely fast, capable of leaping from one roof to the next on the Hanging Garden in seconds.
 * Immense Agility: Issa is very agile and is able to swiftly jump from one of the Hanging Garden roofs to another.
 * Demon Detection: Issa has the strongest supernatural energy detection ability of any living vampire, being able to sense a demon's aura and emotional state from within a three-dimensional range that encompasses the entire Hanging Garden itself.

Trivia

 * Despite being a vampire whom are noted for their strength and pride, Issa is shown to be very weak minded as her fall from grace into madness and death were indirectly caused by her reliance on Zadimus' love just like how Lycidas is dependent on his sister to go on in life despite his overwhelming strength (albeit Lycidas later learned not to monopolize Tsubaki in order to retain her love) and also unlike other vampires which include her son, Issa was ultimately afraid of dying something that vampires in general casually brush off due to their fighting instincts.